Endocrine Abstracts

Objective: The metabolic syndrome (MS) is characterized by a marked sympathetic activation. Whether this adrenergic overdrive is mainly dependent on the obese state or it can be detected also in absence of obesity is unknown, however.Design and Methods: In 25 male patients (age 41.4±yrs., mean±S.E.M.) with MS (ATP III criteria) and in 12 age-matched healthy male controls, we measured body mass index (BMI), waist circumference (WC...

Introduction: While searching for mechanisms contributing to the increased mortality of acromegaly, we have previously described an unexpected sympathoinhibition in newly diagnosed patients (Seravalle et al., Clin Endocrinol 77:262, 2012) and interpreted this finding as an adaptive phenomenon. It has also been shown that centrally administered somatostatin (SS) inhibits peripheral sympathetic outflow in rodents (Rettig et al., Am J Physiol 257:R588, 1989). Ba...